Neuropathology and Functonal, Cognitive, and Neuropsychiatric symptoms
in Misdiagnosed AD 
   Lead Investigator:    Kathryn Gauthreaux
   Institution      :    NACC
   E-Mail           :    kgaut@uw.edu
   Proposal ID      :    276



   Proposal Description:
   Sample: Demented individuals with a clinical diagnosis of primary or contributing     possible/probable AD at their last UDS visit.    Aim 1: Characterize the neuropathology among individuals with a clinical diagnosis of AD and     no/low AD pathology (CERAD neuritic plaque score and Braak stage) at autopsy.     Aim 2: Are individuals misdiagnosed with AD more likely to have FTLD and/or CVD pathology     compared to individuals correctly diagnosed with AD?     Aim 3: Determine whether certain cognitive, behavioral, or functional/motor symptoms are more     or less likely to be exhibited among individuals misdiagnosed with AD (at first visit with AD     diagnosis and at last visit before death).     Aim 4: To examine whether there are different trajectories/patterns of functional/motor,     cognitive, and neuropsychiatric symptoms over time in those misdiagnosed with AD versus     those accurately diagnosed with AD.